Charcot-marie-tooth disease is one of the most common inherited neurological disorders. The symptoms of charcot-marie-tooth (CMT) disease usually start to appear between the ages of 5 and 15, although sometimes they do not develop until well into middle age or later. CMT is a progressive condition, which means that symptoms gradually worsen, making everyday tasks more difficult. CMT is caused by genetic mutations that produce or support proteins involved in the function and structure of either the peripheral nerve axon or the myelin sheath.
Over 40 genes have been identified in CMT, with each gene linked to one or more types of the disease. More than half of all cases of CMT are caused by a duplication of the PMP22 gene on chromosome 17. CMT is caused by an inherited mistake in one of several genes responsible for the development of peripheral nerves. This defect means that the nerves become damaged over time. Gene mutations mostly affect the normal function of the peripheral nerves. CMT can run in a family, even when there is no obvious family history.
Latest report available at Coherent Market Insights indicates that global charcot-marie-tooth disease market is estimated to be valued at US$ 793.9 Million in 2021 and is expected to increase to US$ 3,459.1 Million by 2028, witnessing a CAGR of 23.4% over the forecast period (2021-2028).
Some genetic mutations are hereditary, meaning they can be passed down from a parent to their child. It is caused by hereditary genetic mutations. But just because someone has CMT doesn’t mean they got it from one of their parents. No single faulty gene causes CMT. The many types of CMT are caused by different genetic mutations and faulty genes can be inherited in several different ways. The most common CMT subtypes are CMT1A, CMT1X, HNPP, CMT1B, and CMT2A. All other subtypes accounted for less than 1% each.
There’s no cure for charcot-marie-tooth disease, but braces, physical/occupational therapy, and other orthopedic devices, and even orthopedic surgery can help cope with the symptoms of the disease. CMT cannot be stopped or reversed, but safe and effective treatment can reduce the symptoms of the disease. According to the United States National Library of Medicine, CMT affects around 150,000 individuals in the U.S. Thus, with the increasing prevalence of charcot-marie-tooth disease, the demand for safe and effective treatment is also increasing.
