The risk of adverse sulfamethoxazole side effects (haematological and cutaneous in particular) must take into account is the evolution of the sensitivity of germs to the product and other available antibiotics. Depending on the indications and the germs in question, the first-line antibiotic with the best benefit/risk ratio should be used.
Due to sensitive germs, they are limited to infections in adults, adolescents, children, and infants over 6 weeks of age. There are several Bactrim ds side effects.
- Never take BACTRIM, tablet:
- bactrim allergic reaction also occur In premature babies and infants less than 6 weeks old,
- In case of G6PD deficiency (glucose 6 phosphate dehydrogenase), including when this deficiency concerns the breastfed child (presence of the drug in breast milk): the risk of triggering the destruction of red blood cells,
- In the event of association with treatment with methotrexate there are many bactrim side effects,
- In combination with drugs that are substrates of the OCT2 transporter,
- In the case of liver disease,
- In case of certain kidney dysfunctions
- During breastfeeding bactrim side effects are many,
- In combination with phenytoin, medicines that increase blood potassium
- BACTRIM is not recommended during pregnancy, especially in the 1st trimester.
If a rapidly evolving skin rash occurs, accompanied by fever, blisters or bumps, stop treatment and tell your doctor immediately: risk of a potentially serious skin reaction.
Blood toxic effects were rarely observed. They are more common in older people and people with folate deficiency. Your doctor may need to prescribe blood tests to ensure no abnormality.
It is recommended to drink plenty (2 litres per day) during the treatment to avoid the formation of crystals in the urinary tract. This antibiotic is photosensitizing: even short-term exposure to ultraviolet rays can cause intense sunburn.
Drug interactions bactrim with other substances
This medication should not be combined with methotrexate due to: the risk of bone marrow depression.
Tell your doctor if you are taking an oral antidiabetic from the sulfonamide family or medicine containing one of the following substances: metformin, paclitaxel, pyrimethamine, or ciclosporin.
Fertility, pregnancy and lactation
Occasional use of this medication during pregnancy is possible, provided that the recommended dosage is observed. Nevertheless, its use in the days preceding childbirth must be reported to the doctor; in fact, special monitoring of the newborn may be necessary.
- Feeding with milk:
It is contraindicated during lactation in case of suspected G6PD deficiency in the child or the mother. In general, breastfeeding is not recommended during treatment.
Possible Bactrim side effects
Common: Nausea, vomiting, skin flushing, itching, increased transaminases.
Uncommon: candidiasis, diarrhoea, hepatitis, convulsions.
- Rare or very rare: Inflammation of the gums, neuropathy, dizziness, ringing in the ears, tremor, muscle and joint pain, hallucinations, the increased potassium level, decreased blood sugar, abnormal blood count, lung or kidney damage.
- Allergic reactions and potentially serious skin reactions have also been reported very rarely; they formally contraindicate the continuation or resumption of treatment.
- General Disorders:
Increased body temperature, allergic shock, angioedema (a variety of urticaria usually causing swelling of the face beginning in the eyelids and more rarely in the throat), serum sickness (fever, joint pain, hives).
- Digestive disorders:
Nausea, vomiting, stomach pain, diarrhoea, inflammation of the oral mucosa (stomatitis), glossitis (swollen tongue, darker red, smooth), and pancreatitis (inflammation of the pancreas).
- Liver disorders:
There is a frequent increase in liver enzymes, high bilirubin levels, hepatitis (inflammation of the liver), jaundice, and destruction of liver cells.
Isolated cases of destruction of the ducts collecting bile in the event of prolonged liver damage.
- Blood manifestations:
Possibility of changes in the blood balance (thrombocytopenia, leuko-neutropenia, agranulocytosis, bone marrow depression, hemolytic anaemia, megaloblastic anaemia, cytopenia,
decrease in the number of blood cells (platelets, white blood cells, red blood cells), which may result in small red or purple patches of skin bleeding from the nose or gums
Unexplained fever paleness or intense fatigue, abnormal levels of a pigment in the blood, which may manifest as greyish discolouration of the skin (methemoglobinemia).
- Hearing disorders:
Tinnitus (for example, buzzing or ringing in the ears).
- Neurological disorders:
Neurological manifestations such as numbness or tingling of the hands or feet have been observed, as well as signs of meningitis (headache, stiff neck, difficulty in bearing light, vomiting, impaired consciousness), convulsions, dizziness, tremors, balance disorders (ataxia), cerebral vasculitis (inflammation of the vessels of the brain).
Cases of uveitis have been described (inflammation of the eye’s internal structures, which manifests as decreased vision and often as eye redness and pain) and retinal vasculitis (inflammation of the vessels in the retina).
- Isolated cases of hallucinations.
- Manifestations in patients with HIV / AIDS infection
- When administered at high doses, certain adverse effects may appear more frequently, such as skin reactions and fever, generally associated with other symptoms such as loss of appetite, nausea with or without vomiting, diarrhoea, and reduction in white blood cells. , decreased number of blood cells (platelets), increased liver enzymes, increased blood potassium, reduced blood sodium, and hypoglycaemia (low blood sugar).
- Cases of pancreatitis (inflammation of the pancreas) and rhabdomyolysis (rare serious muscle disorders) have been reported in patients receiving concomitant treatments likely to cause such effects.