Will CBD oil interact with other medications?

by Carter Toni

CBD has gushed into the market with various products available in a variety of flavors for the customer’s convenience. Many people embraced CBD and welcomed its benefits in their life owing to few negatives but plenty of advantages for everyday ailments. Not only is CBD useful in treating insomnia and chronic pain, but it’s relaxing and stress-releasing properties also make it appealing to every adult age group. But you must be careful when using CBD with other medications for your minor or major ailments. CBD oil tincture that works may also react to a certain degree, causing the pills to escape their benefits, leading to detrimental effects on health.

What is CBD oil?

Cbd oil refers to the cannabidiol extracts from hemp or cannabis plants obtained naturally that have calming effects on your body and mind. It is one of the major compounds found in cannabis, apart from THC and over 100 other compounds.

THC is delta-9-tetrahydrocannabinol that is an active ingredient and causes the high associated with hemp intake. It is the most sought after due to its natural origins and hence a safer option against other psychoactive drugs, but it is not advisable for consumption daily.

CBD or cannabidiol, on the contrary, is a safe, non-psychoactive element that is similar to THC in composition 21 carbon atoms, 30 hydrogen atoms, and two oxygen atoms, but different in chemical structure. The difference in their chemical structure and bond retains CBD as non-psychoactive but gives THC psychoactive properties.

Cbd binds with the endocannabinoid system.

How to incorporate CBD

CBD is available in various forms of edibles as CBD gummies, CBD sleep oils with CBN, tinctures, balms, vapes, and bath bombs.

Suppose you are using CBD for pain medication/insomnia therapy. In that case, you may need fixing your dose as you will be required to consume CBD medication daily to be economically viable and reasonably potent every day. Arthritis or joint pains can be treated with balms and softgels, applied directly to the local area of pain. Cbd gummies and oils also help with anxiety and depression and help elevate mood and relax your body.

CBD oil tincture that works with full-spectrum is known for its entourage effect. That implies the interaction of pure hemp extract and all its cannabinoids, terpenes, flavonoids, THC (<0.3%), and CBD in the highest concentration binds together with the human endocannabinoid system and present the entourage effect beneficial to the mind and body and regulates the mood disorders.

What is a drug interaction?

Drug interaction or DDI refers to the drugs present in the medications that may interact with each other depending on the concentration, tolerance/resistance, and period of regular use.

The most important enzyme in the human digestive system involved in drug metabolism is CYP450 for converting foreign substances to be cleared off from the body. CYP450 enzymes are implicated in the primary metabolism and biotransformation of the majority of therapeutic agents and xenobiotics. But the isomers of CYP450 are associated with the drugs that are involved as inhibitors and inducers. To say it, the CYP450 is associated with medications that are most commonly used to treat epilepsy, chronic wasting disease in HIV/AIDS, and cancer. Thus, increasing the chances of interaction and lowering or concentrating the dose of medication.

It also implicates the possibility of interaction with other medications. CYP3A4/2C19 inhibitors, substrates, and inducers are also present for common medicines for natural diseases like hypertension, migraine, heartburn and are used acutely and chronically. These interactions can potentiate a wide array of adverse drug effects and negative clinical outcomes specific to the substrate and indicated treatment. 

Factors influencing the interaction of CBD and other medications:


The effects of CBD on your body are highly dependent on the way you use it. Some prefer to consume it in the form of CBD gummies and other edibles that allow it to pass through your digestive system and have reduced effects while binding to the CB1 and CB2 receptors of the endocannabinoid system. As it should go through the digestive process before getting absorbed in the bloodstream, you will see that the effects of CBD are not only limited but also delayed and hence must be taken into account for the same. CBD can react with supplements, herbal products, and over-the-counter (OTC) and prescription medications. It also has time to react with other medicines that you might be on.

It has a higher potential to interact with the medication when you consume CBD through vaping or smoking as it is directly introduced in the bloodstream by inhaling through the lungs. When on medication, it interacts with the components present in the bloodstream to nullify or magnify the effects and hence is a potential health hazard. Therefore, before trying CBD, you must consult your doctor and inquire about the medications and their interaction with CBD.

The interaction also depends on the concentration of CBD in the products that you consume. Cbd isolate/broad-spectrum will be less reactive when compared to CBD full spectrum as most of the cannabinoids, terpenes, and flavonoids are eliminated in the preceding formula. Also, the concentration of CBD varies from brand to brand and dose to dose. You must understand the details with your doctor before consuming CBD in any form if you are already on any medication.

Be careful if you are on cancer treatment/medication, as these are heavy-dose tablets and formulas that may cause CBD to react inappropriately with CBD. Antidepressants (such as fluoxetine or Prozac), Macrolide antibiotics (erythromycin, clarithromycin), Medications that can cause drowsiness (antipsychotics, benzodiazepines), Heart medications (some calcium channel blockers) may also cause adverse effects on the body. 


CBD will not have unpredictable effects even when combined with medication, but you must be careful if you are on a long-term medication course for any chronic disease. Consult your doctor before you administer any dose of CBD as a precautionary step against reactions and side effects.

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